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ANTIBACTERIAL ACTIVITY OF 4-HYDROXYCHALCONE AGAINST BACTERIAL CONTAMINANT OF PACKED RED CELLS
- Bagikan:
The bacterial contamination of blood products is still become a serious
problem in consideration, thus it can cause the risk of blood transfusion,
namely bacterial sepsis. Packed red cells is blood product and potentially
contain bacterial contaminant. The source of bacterial contamination can
come from the skin disinfection process in less aseptic during blood
collection, donor bacterimia, and blood processing. In response, currently
there have been many antibacterial compounds developments purposely to
reduce the risk of bacterial contamination of blood products. This study
aimed to observe the activity of 4-hydroxychalcone compounds in
contaminant bacteria isolated from packed red cells blood products.
Bacterial isolates isolated from the packed red cells were Staphylococcus
aureus based on cell morphology, biochemistry and colony shape. The
antibacterial activity of 4-hydroxychalchone compound against
Staphylococcus aureus isolates used the diffusion method. The results
showed, there were antibacterial activity of 4-hydroxychalchone at a
concentration of 2.5% 1.25% and 0.625% against packed red cells
contaminant bacteria based upon the clear zone formed. In conclusion, the
bacteria isolate was obtained from the PRC was gram positive bacteria,
Staphylococcus aureus. The 4-hydroxychalcone had successfully
synthesized and has antibacterial activity against S. aureus isolated from
PRC, with the biggest inhibition power was 71,36% at 5,0% of chalcone
concentration.
Detail Information
| Item Type |
Other
|
|---|---|
| Penulis |
Aulia Rahman, S.Si., M.Biotech - Personal Name
|
| Student ID | |
| Dosen Pembimbing | |
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edisi |
Published
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| Departement | |
| Kontributor | |
| Bahasa |
English
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| Penerbit | UNTIDAR : indonesian Journal of Biology., 2022 |
| Edisi |
Published
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| Subyek | |
| No Panggil | |
| Copyright | |
| Doi |